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GEN ; 64(4): 341-343, dic. 2010. graf
Article in Spanish | LILACS | ID: lil-664520

ABSTRACT

Los pacientes con cáncer son población de riesgo para adquirir infección por virus de hepatitis B por estar expuestos a métodos que favorecen la inoculación parenteral del virus. Cuantificar los anticuerpos contra el antígeno de superficie para el virus de hepatitis B en pacientes sin títulos protectores al momento de su ingreso en el servicio de hematooncología pediátrica que recibieron un esquema corto de vacunación (0, 1 y 2 meses). Entre marzo de 2008 y 2009, se recibieron 40 pacientes, excluyéndose 17 posteriormente del estudio, 8 por presentar marcadores positivos de infección para hepatitis B y 9 con títulos mayores de 100UI/L. Dieciséis pacientes sin títulos protectores recibieron vacuna recombinante. Se determinaron serologías para hepatitis B: Antígeno de superficie, Anticuerpo contra el antígeno de superficie y anticore, cada 3 meses, por 1 año, considerándose como títulos protectores anticuerpo contra el antígeno de superficie mayor de 100UI/L De los 16 (100%) pacientes que recibieron vacunación, 15 (94%) alcanzaron títulos protectores, los cuales presentaron descenso del anticuerpo contra el antígeno de superficie durante el tiempo de estudio. Los pacientes vacunados alcanzaron seroprotección con posterior disminución progresiva de sus títulos protectores lo que justifica su revacunación...


Patients with cancer are a population in risk of being infected by Hepatitis B virus as a consequence of being exposed to methods favoring the parenteral inoculation of the virus. Quantifying the antibodies against the surface antigen for Hepatitis B virus in patients without protection titers when admitted to the pediatric hematology-oncology service and who received a short vaccination schedule (0, 1, and 2 months). Between March 2008 and 2009, 40 patients were received, from which later on 17 were excluded from the study since 8 showed infection positive markers for Hepatitis B, and 9 with values higher than 100IU/L. 16 patients without protection titers were recombinant- vaccinated. Serologies for Hepatitis B were determined: Surface Antigen, Antibody against surface antigen, and anticore every 3 months during 1 year, being considered as the antibody protectors against the surface antigen higher than 100IU/L. Out of the 16 patients (100%) who were vaccinated: 15 (94%) reached protection titers, showing antibody decrease against surface antigen in the study term. Vaccinated patients reached seroprotection with later progressive diminishing of protection titers, thus justifying revaccination...


Subject(s)
Humans , Male , Female , Child , Hepatitis B/pathology , Neoplasms/complications , Neoplasms/pathology , Hepatitis B Vaccines/therapeutic use , Gastroenterology , Medical Oncology , Pediatrics
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